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Protein Engineering Excellence
Accelerating Tomorrow's Antibody Therapeutics Today
Antibodies • Proteins • Bispecifics • Multispecifics • ADCs • AI • Computational Breakthroughs
The Summit of Antibody Science and Your Path to Commercial Success
Final 2026 Agenda Now Live!
The Complete 2026 Agenda in now available!
Download the full 2026 agenda to find out what's in store for December!
Early registration is now open!
Register today at the lowest price for this event. You can save up to $1,100 when you book by Friday, July 24.
Confirmed 2026 Keynotes!
Master cutting-edge antibody engineering techniques that you can immediately apply in your own R&D programs.
Discover What’s Coming in 2026!
After an insightful and unforgettable event last year, the 2026 edition promises even more breakthroughs in antibody science and innovation.
- 4 Days of antibody science and innovation
- 900+ International Attendees connecting and collaborating
- 165 Global Expert Speakers presenting insights across antibody engineering and therapeutic development
- 97 Sponsors showcasing cutting-edge solutions
- 158 Posters showcasing the latest discoveries from leading scientists worldwide
- 10 hours of dedicated networking including receptions, social hours, and poster viewing
- Global impact across US, Europe & Asia
Antibody Engineering is Experiencing Unprecedented Innovation. Are You Leading or Following?
This event is a strategic investment for your R&D teams to fast-track antibodies from discovery to the clinic and beyond by applying cutting-edge innovation across AI, computational breakthroughs and beyond.
From Discovery to IND: What Matters Most and How to Get it Right
- Balance efficacy with manufacturing complexity in bispecific design
- Apply quantitative pharmacology from dose selection through optimization
- Leverage tetravalent platforms to enhance potency while minimizing toxicity
Engineering Considerations for Candidate Selection and Developability
- Implement computational cascades for multispecific antibody optimization
- Evaluate format selection impact on biophysical properties and developability
- Deploy polyspecificity profiling for early liability identification
Expanding Therapeutic Applications: Utility of Antibodies Beyond Oncology
- Target cytoplasmic proteins with AAV-delivered intrabodies for neurodegeneration
- Combine CD3 and CD28 engagers to overcome immunosuppressive microenvironments
- Deliver selective payloads to inflammatory cells using ADCs
Beyond Bispecifics: The Next Wave of Tri- and Multi-Specific Antibodies
- Engineer trispecific T cell engagers for optimal activity and therapeutic indices
- Deploy bispecific ADC platforms to eliminate cancer and immunosuppressor cells
- Build robust IP portfolios through sequence optimization and epitope characterization
Engineering Solutions for Accessing Difficult Targets
- Enable oral delivery of biologics through retro-transcytosis mechanisms
- Design tumor-activated cytokine platforms with protease-triggered masking
- Leverage tissue-specific B-cell phenotypes for enhanced autoimmune therapeutics
Advanced In Vivo Approaches to Antibody Discovery
- Unlock undruggable targets using transgenic mouse models with AI
- Harness germinal center processes to enhance antibody breadth and potency
- Expand discovery toolkit with mRNA and protein/DNA cage immunization
Engineering Innovative Functionality into Antibody Domains
- Design Fc variants for enhanced potency, effector silencing, and persistence
- Engineer FcγRIIB-selective fusion proteins for targeted autoantibody clearance
- Develop pan-subclass IgG reduction strategies for broad immunoglobulin depletion
Antibody Engineering for Proximity-Based Approaches
- Modulate immune checkpoint signaling at microvillar T-cell contact sites
- Achieve rapid internalization through high co-crosslinking of surface proteins
- Engineer precision control of B cell activation with anti-CD19 antibodies
Engineering Antibody Interfaces: Unlocking New Biology
- Expand epitope recognition through novel homotypic antibody interfaces
- Optimize nanoscale spatial organization to determine therapeutic function
- Control heavy-light chain pairing in bispecifics with extended half-life
Engineering and Biological Principles for Cell Engagers
- Target tumor-specific pMHC complexes for highly selective solid tumor therapy
- Deliver dual signals to overcome immunosuppressive microenvironments
- Implement CD8-guidance and logic-gated platforms for enhanced safety
Emerging In Vitro Approaches to Antibody Discovery
- Apply machine learning to analyze epitopes and binding specificity at scale
- Accelerate candidate identification with computational antibody and TCR modeling
- Generate conformationally-restricted agonistic antibodies through structure-guided engineering
Beyond Classic ADCs: Novel Payloads, Modalities, and Mechanisms
- Expand ADC toolbox with non-natural amino acids and dual-payload designs
- Deploy radioimmunoconjugates for targeted radiation therapy with minimal toxicity
- Selectively deplete disease-driving immune cells with next-generation ADC platforms
What’s Waiting for You in Sunny San Diego
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Expert Speakers in Advanced Antibody Development
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Antibody Scientists, Researchers & Industry Professionals
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Next-Generation Solution Providers
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Scientific Posters Highlighting Pioneering Research
Ways to Attend
Join the Antibody Event of the Year in San Diego!
Get ready for 4 days of breakthrough science, powerful networking, and cutting-edge innovation at Antibody Engineering & Therapeutics US. This is your chance to:
✔ Access exclusive insights from 135+ world-renowned speakers sharing never-before-seen data and real-world case studies.
✔ Connect with 75+ leading solution providers driving the next wave of antibody engineering and therapeutic development.
✔ Explore the entire antibody landscape - from discovery and design to clinical development and commercialization.
Whether you’re passionate about bispecifics, ADCs, AI-driven discovery, or next-gen formats, this is where the future of antibody therapeutics takes shape.
Join us in sunny San Diego or tune in virtually from anywhere!
Showcase Your Research – Add a Poster Presentation
When you register for an in-person or digital Main Conference Pass (or Main Conference + Workshop Pass), you’ll have the exclusive opportunity to elevate your experience by adding a poster presentation for just $199.
This is your chance to:
✔ Showcase your research to leading scientists and industry innovators
✔ Spark meaningful discussions and gain valuable feedback
✔ Expand your professional visibility within the global antibody community
Don’t miss this opportunity to amplify your presence and make an impact!
Partner with the World’s Leading Antibody Event
Seize the opportunity to connect with key decision-makers and industry pioneers shaping the future of antibody therapeutics. As a sponsor of Antibody Engineering & Therapeutics US, your brand will be front and center at the industry’s most influential event, giving you:
✔ Unparalleled access to top biopharma leaders and innovators
✔ Opportunities to showcase your solutions to an engaged audience actively seeking new technologies and partnerships
✔ Direct connections that accelerate your business growth in the antibody and protein therapeutics market
Don’t miss your chance to position your brand at the forefront of antibody innovation.
The Antibody Society: Driving the Future of Antibody Science
The Antibody Society is a global non-profit organization uniting researchers, developers, and industry leaders advancing antibody science. Through data analysis, publications, webinars, and symposia, we connect the community with the insights and standards that shape next-generation therapeutics. We’re also proud to serve as the home of the Adaptive Immune Receptor Repertoire (AIRR) Community, dedicated to innovation and best practice in sequencing antibodies and T cell receptors.
Our members play a vital role as Scientific Advisors for the Antibody Engineering & Therapeutics conferences, ensuring each program reflects the very latest breakthroughs in discovery, development, and delivery.
👉 Special Benefit for Members: Antibody Society members enjoy exclusive savings on conference registration — including 15% off Antibody Engineering & Therapeutics US 2026.
Engage Quality Decision-Makers at Antibody Engineering & Therapeutics US!
Whether you're looking to generate quality leads, showcase thought leaders, or reinforce your brand, collaborate with us to identify custom sponsorship opportunities to help you reach your business objectives.
Contact us to begin customizing your event presence today:
Companies A-L: Alexandra Kapetanopoulos, AKapetanopoulos@informaconnectls.com
Companies M-Z: Blake Shuka, BShuka@informaconnectls.com
FAQs
What is Antibody Engineering & Therapeutics US?
Antibody Engineering & Therapeutics US is the premier conference for antibody science and innovation. For over 30 years, it has served as a global meeting place bringing together leading academic and industry experts to share cutting-edge research, technology advances, and therapeutic breakthroughs in antibody engineering.
When and where is Antibody Engineering & Therapeutics US 2026 taking place?
The event will be held from December 13-16, 2026, at the Marriott Marquis San Diego Marina, located at 333 West Harbor Drive, San Diego, CA 92101, USA.
Who organizes Antibody Engineering & Therapeutic conferences?
This event is organized by Informa Connect, part of Informa PLC. It also serves as the annual meeting of The Antibody Society, whose members are responsible for designing the scientific program and acting as session chairs.
As well as the US event in San Diego, we also organize Antibody Engineering & Therapeutics Europe and Antibody Engineering & Therapeutics Asia.
Find out more about Informa Connect Life Science events here.
Who should attend this conference?
This event is ideal for antibody scientists, researchers, industry professionals, academic experts, and anyone involved in antibody engineering, design, selection, and therapeutic development. Our content is tailored for professionals at all career stages who are passionate about advancing antibody science.
What topics will be covered at the conference?
The conference will cover cutting-edge topics in antibody science and technology, including:
- Bispecific antibodies
- Antibody-drug conjugates (ADCs)
- Protein-based degraders
- Immuno-oncology
- Antibody therapies for neurodegenerative diseases
- Tumor microenvironment in antibody therapy
- Antibody immune agonists
- Latest advances in antibody engineering and design
Will there be networking opportunities?
Absolutely! We pride ourselves on creating meaningful connections. Our carefully designed networking sessions will give you ample opportunity to meet industry leaders, potential collaborators, and peers who share your passion for antibody science.
Can companies exhibit at the conference?
Yes, we welcome exhibitors who wish to showcase their innovations to our engaged audience of antibody professionals. We're pleased to announce that several organizations have already confirmed their participation, including Biointron and Creative Biolabs.
How can my company become an exhibitor or sponsor?
We offer a range of tailored exhibition and sponsorship packages to help you connect with our audience. Please contact our dedicated sponsorship team: [Companies A-L] Mia Crisafulli, MCrisafulli@informaconnectls.com / [Companies M-Z] Blake Shuka, BShuka@informaconnectls.com to discuss how we can help you achieve your objectives.
You can also download our sponsorship brochure here.
How long has this conference been running?
What makes this conference unique?
As the flagship conference for antibody science and innovation, it brings together the world's leading academic and industry experts to share research, technology advances, and therapeutic breakthroughs. It's recognized as one of the top antibody and protein engineering conferences for accelerating next-generation antibodies to commercial success.